uBeat® Technology
The uBeat® platform supports the culture of 3 biologically independent 3D microtissues within a single device.
In each culture chamber microfluidic channels are separated by rows of hanging pillars. Geometry of
these features dictates the mechanical stimulation received in the cell construct.
The uBoX actuator pressurizes the actuation layer
underneath the cell culture layer to transfer a
controlled mechanical stimulation to the cell constructs by means of the patented uBeat® technology.
The uBeat® technology can be adopted to both maturate and differentiate human tissue in vitro and to develop mechanically-related pathologies on chip.
Geometry
Mechanical
Stimuli
The stroke distance only depends on the pillars' gap.
The pillars gap modulates the stimulation intensity.
The type of stimulation is defined by the pillars' shape.
uBeat®Platform
Cell Culture Layer Top View
Cell Culture Layer – Top View
High Data Content
Miniaturized
3D microtissue: small volumes vs high cell density
Compatible
With standard biological assays and protocols Live/Dead assays Immunofluorescence PCR ELISA Dextran Permeability Proteomics Mass Spectrometry
The uBeat® technology can be adopted to both maturate and differentiate human tissue in vitro and to develop mechanically-related pathologies on chip.
